Interesting Missing Number Picture Puzzle with Answer

This is very interesting missing number picture puzzle in which some group of numbers are given in Circles. These numbers are related to each other with some Mathematical series or pattern. Can you find this series or pattern and then calculate the value of missing number which will replace the question mark?
Interesting Missing Number Picture Puzzle
Can you find the missing number?

Answer can be viewed by clicking on button. Please do give your best try before looking at the answer.

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